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Early signs and symptoms following a most likely hepatotoxic overdose might contain: nausea, vomiting, diaphoresis, and general malaise. Scientific and laboratory proof of hepatic toxicity may not be obvious until eventually forty eight to 72 several hours publish-ingestion.When this medication is utilised for years, it might not get the job done a

Acetaminophen is metabolized in the liver by using cytochrome P450 microsomal enzyme. About 8085% in the acetaminophen in your body is conjugated principally with glucuronic acid and also to a lesser extent with sulfuric acid and cysteine. After hepatic conjugation, 90 to one hundred% from the drug is recovered in the urine with in the first day.Vi